Post by barnabaslives on Jul 13, 2018 19:51:12 GMT
I wouldn't read too much into this, but I am very happy to see it since someone needs to figure out why our antibiotics seem to be failing us so often, and over the last six months I have arrived at the opinion that DNA repair proteins like RecA may be absolutely vital to an understanding of the problem and a more optimistic outlook. We need more like this, IMHO. Timing is key for bacteria surviving antibiotics (If anyone's interested in learning more about the subject of how microbes and antibiotics interact,
Brynildsen's colleagues & co-authors and some of theirs - Collins, Dwyer, Kohanski - may be particularly worth keeping an eye on).
In my opinion, a lot of the troubles we have with antibiotics may have less to do with "wearing them out" and more with - believe it or not - our not really knowing how antibiotics work in the first place. (We've also probably gotten ourselves into considerable trouble by not being more focused on both the lack of homogeneity in microbial biofilms, and their penchant for both clinical subtlety, and diversity). I've found so many loopholes in "conventional wisdom" on antibiotics that recently, I finally ended up just throwing out everything we think we know, and starting over - which would be a very lonely and desolate place to be indeed if it weren't for the fine company of the aforementioned individuals and thoughtful souls like them.
I'm particular grateful for some of this research since I've struggled with chronic illnesses for at least 35 years now and still don't have a great deal of hope of getting something done about the situation - even with some of the amazing research we've had on one diagnosis after another showing the predictable (if often elusive) presence of particular microbes, we still too often have doctors' "trusted sources" telling physicians the very opposite about the presence of microbiota, a serious problem further confounded by the typical unexplained failures of antimicrobial agents. We seem to have a lot left to learn about medicine, so a tip of my hat to these pioneering spirits who are trying to make sure we're learning some of what we really need to know.
Brynildsen's colleagues & co-authors and some of theirs - Collins, Dwyer, Kohanski - may be particularly worth keeping an eye on).
In my opinion, a lot of the troubles we have with antibiotics may have less to do with "wearing them out" and more with - believe it or not - our not really knowing how antibiotics work in the first place. (We've also probably gotten ourselves into considerable trouble by not being more focused on both the lack of homogeneity in microbial biofilms, and their penchant for both clinical subtlety, and diversity). I've found so many loopholes in "conventional wisdom" on antibiotics that recently, I finally ended up just throwing out everything we think we know, and starting over - which would be a very lonely and desolate place to be indeed if it weren't for the fine company of the aforementioned individuals and thoughtful souls like them.
I'm particular grateful for some of this research since I've struggled with chronic illnesses for at least 35 years now and still don't have a great deal of hope of getting something done about the situation - even with some of the amazing research we've had on one diagnosis after another showing the predictable (if often elusive) presence of particular microbes, we still too often have doctors' "trusted sources" telling physicians the very opposite about the presence of microbiota, a serious problem further confounded by the typical unexplained failures of antimicrobial agents. We seem to have a lot left to learn about medicine, so a tip of my hat to these pioneering spirits who are trying to make sure we're learning some of what we really need to know.