The Diary of River Song Vol.1 (Spoilers)

No doubt BF have already given this a lot of thought and probably have a good story reason why River can interact with many Doctors. I'm all for it given the nature of the character. She's one of a few characters that can conceivably stretch across any era of Who. I agree with previous posters in that I very much want to see River's stories stand on their own so I think there should be plenty of them that are completely Doctorless. However, sprinkling in various incarnations of the Doctor in fun and unexpected ways could be a unique element of the River series.

I'm not sure if I would buy the idea that the Doctor has met her before and simply doesn't remember. River definitely makes an impression. The explanation would have to do a bit more than just say he forgot over the course of the centuries, especially if she does wind up interacting with the Doctor over many different regeneration's.

Also hoping she'll have some adventures with mom and dad and I would really really love it if she had an adventure with Rory's father. That's comedy gold.

I can see that. Of all the current series characters getting a range, this is the one I'm most curious about. River Song is a character where, for me at least, a little goes a long way. I don't know if that is in the character's DNA or if it is a product of the way Steven Moffat tends to write his strong female characters. I suppose the question I keep asking is in a universe where we have Benny running around, do we really need River Song? But then I ask the same question about Counter Measures, UNIT and Torchwood.